A prototype for continuous security awareness in financial institutions

Information security is recognized as a management issue. Sarbanes-Oxley specifies that management is ultimately responsible for the security, accuracy, and privacy of information relating to corporate financial records and by ricochet the protection of Personally Identifiable Information (PII). Many organizations have established information security program. One of the key components of an information security program is to build security awareness as humans are considered as the weakest link of the security chain. In order for security awareness programs to add value to an organization and stay effective against the threat against human hacking, it is important to measure and continuously improve its effectiveness. This paper uses design science research approach to propose a prototype for continuous security awareness improvement in financial institutions. The prototype will be contribution in the information security field and will guide decision makers at financial institutions in their choice of security awareness product

N-(1,3-Diaryl-3-oxopropyl)amides as a new template for xanthine oxidase inhibitors

A series of forty two N-(1,3-diaryl-3-oxopropyl)amides were synthesized via an efficient, modified Dakin–West reaction and were evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Structure–activity relationship analyses have been presented. Selected active xanthine oxidase inhibitors (3r, 3s, and 3zh) were assessed in vivo to study their anti-hyperuricemic effect in potassium oxonate induced hyperuricemic mice model. Compound 3s emerged as the most potent xanthine oxidase inhibitor (IC50 = 2.45 lM) as well as the most potent anti-hyperuricemic agent. The basis of significant inhibition of xanthine oxidase by 3s was rationalized by its molecular docking into catalytic site of xanthine oxidase

A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors

Xanthine oxidase is a complex molybdoflavoprotein that catalyses the hydroxylation of xanthine to uric acid. Fifty three analogues of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles were rationally designed and synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Some notions about structure activity relationships are presented. Six compounds 41, 42, 44, 46, 55 and 59 were found to be most active against XO with IC50 ranging from 5.3 lM to 15.2 lM. The compound 59 emerged as the most potent XO inhibitor (IC50 = 5.3 lM). Some of the important interactions of 59 with the amino acid residues of active site of XO have been figured out by molecular modeling